bluetongue virus in humans

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Many can be passed transovarily in the arthropod host, others can survive in diapausing insects.

Most have evolved ways to persist in the invertebrate host during periods of inactivity. Arboviruses must be able to survive such periods of low vector activity, and different arboviruses have solved this problem in different ways. The orbiviruses can infect a wide range of host species including ruminants, camelids, equids, marsupials, bats, seabirds and in some cases humans. Bluetongue Virus. Most of the clinical signs can be reconciled with damage of the endothelium of small blood vessels.Sheep surviving bluetongue are protected against subsequent BTV infections by acquired immunity that is fully protective against homologous serotypes. Bluetongue virus (BTV) is endemic in some areas with cattle and wild ruminants serving as reservoirs for the virus. There is a marked loss of condition, and death can occur up to 1 month after infection. In sheep, susceptibility to bluetongue varies among different breeds. Virions are double-layered particles containing 10 genome segments.Rotaviruses are transmitted by the fecal oral route. Cattle, goats and elk, for example, are affected by a very mild, self-limiting infection.Bluetongue can cause serious illness and death in sheep as well as deer and potentially other wildlife. In tropical areas of the world, arthropods may be continuously active and viruses associated with such arthropods may persist by continuous passage between the vertebrate and the invertebrate host. 2015 Aug;34(2):329-40. doi: 10.20506/rst.34.2.2360. The primary reservoirs are rodents and birds, and infection of humans following a tick bite can lead to a febrile meningoencephalitis but without paralysis, similar to the better-known tick-borne encephalitis (TBEV) a flavivirus.The orbiviruses have a 10-segmented dsRNA genome that is packaged within a three-layered icosahedral protein capsid (The innermost capsid shell of BTV (the subcore) is composed of 120 copies of the essentially triangular VP3(T2) protein (901 amino acids, 103 kDa, encoded by BTV genome segment 3). There are 21 different strains of Bluetongue that have been identified. In Canada, the presence of the virus is usually restricted to late summer and early fall, since conditions must be warm enough for the bluetongue virus to multiply within the midge (13°C to 35°C).

For example, in 1997, a new Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition)Christopher J. Burrell, ... Frederick A. Murphy, in Fenner and White's Medical Virology (Fifth Edition)The structure of bluetongue virus core and proteinsViral Pathogens of Domestic Animals and Their Impact on Biology, Medicine and AgricultureViruses That Contain Double-Stranded RNA: Family ReoviridaeScienceDirect ® is a registered trademark of Elsevier B.V. Subcore particles of some orbiviruses, for example, equine encephalosis virus (EEV), are also stable in the absence of the outer capsid layers (The outer surface of the BTV core is composed of 780 copies of the VP7 protein (349 aa, 38.5 kDa, encoded by genome segment 7), arranged (as 260 trimers) with Two orbiviruses within the family of the Reoviridae are the causative agents of two similar infectious, noncontagious, insect-borne diseases of sheep and horses: bluetongue of sheep and AHS.Bluetongue is caused by bluetongue virus (BTV), a member of the genus All ruminants are susceptible to BTV infection but sheep are, by far, the most affected domestic species, followed by goats and white-tail deer in the United States.

Infection in cattle is in general subclinical, but it has a considerable epidemiological significance for the maintenance of BTV in an endemic area. Although the disease is not a threat to humans, the most vulnerable common domestic ruminants in the UK are cattle, goats, and especially, sheep. In Canada, Type 11 Bluetongue virus was isolated in 1987 and 1988 in the Okanagan Valley of British Columbia. Orbiviruses, in contrast, have evolved a mechanism to persist in the vertebrate host for long periods. PMID: 26601438 DOI: … However, in many areas of the world, including some tropical areas, the vector activity may become low or nonexistent during some periods, such as the dry season or the winter. New orbiviruses have been isolated from both insect and tick vectors, as well as their mammalian hosts (The orbiviruses are ten-segmented double-stranded RNA viruses that comprise the largest genus within the family The distribution of BTV is almost entirely dependent on the distribution, activity, and seasonal abundance of competent vectors (i.e., adults of certain Orbiviruses are transmitted by insects. In general, breeds from tropical countries in Africa and Asia do not display severe clinical signs upon infection.BTV is transmitted by an insect vector, the biting midge of the Bluetongue is present in most tropical and subtropical regions of the world and lately several incursions have been recorded in southern Europe and subsequently in Central and even northern Europe. Bluetongue is caused by reoviruses. A puzzling aspect of BTV is its survival between midge seasons in temperate regions.

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