I need to give it to my mouse at a dose of 10 mg/Kg. In case of poly herbal formulated tablet how to convert the human dose to animal dose for preclinical research?I have a drug that in its catalog is written resuspended in DMSO. Top Menu.
You can add the saline more rapidly once the volume increases.
The concentration is the mass of medicine contained in a volume of liquid. You may need to warm the solution slightly. Methods: Pts were enrolled with noncurable cancers, ≤1 prior regimen...Join ResearchGate to find the people and research you need to help your work.© 2008-2020 ResearchGate GmbH. Use at your own risk. BA Moore Pharmaceutical Consulting, LLC, Collegeville, PA, United StatesRachel - a 20 gram mouse is one-fiftieth of a kg (1000/20). I have an undiluted drug in powder form. I'm planning to inject intracerebroventricularly (ICV), is there a standard/empirical way to determine the concentration/dose to start with?I have 3 groups. Skip to content. 1.
Medication Usage Chart for Rat Respiratory Illnesses and Other Conditions.
Control 2. Therefore to dose at 10 mg/kg, you need to divide your dose by 50 which means your 20 g mouse should receive 0.2 mg (10/50). References. This trial sought to assess the maximum tolerated dose, dose-limiting toxicities (DLTs), tumor response, and the recommended Phase II dose of a P+D combination planned for pts with advanced cancer. Then a 20 g mouse would receive 200 uL, a 25 g mouse would receive 250 uL, etc. Would appreciate if one can provide complete answer. The label on the medicine bottle states the concentration of the medicine. By using this calculator you acknowledge any reliance on this calculator shall be at your sole risk.
If the drug is 95% pure for example, then you will need to make your stock solution at 2.1 mg/ml to account for the reduced amount of active drug. The drug is docetaxel and its MW is 807.87922. Add the saline slowly at first (a few drops at a time) with stirring to avoid the drug crashing out of solution.
Thus you are restricted to smaller volues.
Software programs, calculations, solutions, answers and calculators are intended for education purposes only.
The label on the medicine bottle states the concentration of the medicine. injection into a mouse of up to 200 ul? 24 hr ÷ 8 hr = 3 The doctor has ordered the medication to be given 3 times per day. Register; Login; Pharmacy Technician-Certified: Regions Hospital - Pharmacy Technician-Certified+ Job ID:56063+... 305551 1Clin Pharma I Inpat: Penn Medicine - The Pharmacy department at the Hospital … With the use of any information on this site, the user shall assume/take sole responsibility for any consequences or damages. This can now be diluted 1:20 with saline. If the drug is 95% pure for example, then you will need to make your stock solution at 2.1 mg/ml to account for the reduced amount of active drug. The easiest way to dose mice at 10 mg/kg is to prepare a 1 mg/ml stock solution.
Is there any other better way to calculate the gene expression results better?p.s I have attached the .xls file for your reference.Is there a way to covert in vivo dose to in vivo concentration, or vice versa?I was wondering if there's any way of converting an in vivo dose e.g., 3 mg/kg in mouse, into a concentration that can be used in in vitro assays, or vice versa. Mary Ann Isaksen and Daryl Mabley, D.V.M.
You don't even have to think about it. Is it toxic for injection I.P. Disease 3. One additonal consideration: Is your drug pure or is it mixed with an excipient?.
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